Testicular Torsion Following Reperfusion Injury in Rat Model: Can Vitamin E Palliate this Injury?
Adekeye A.O , Akintayo C.O , Sanya J.O. , Enye L.A ,
Corresponding Author : Akintayo C.O,
Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.
Email ID : firstname.lastname@example.org
Received : 2015-02-02 Accepted : 2015-03-09 Published : 2015-03-09
Abstract : This study seeks to investigate in a rat model the effect of vitamin E following reperfusion injury/testicular injury. Twenty (20) Wistar male rats weighing between 100-150g ranging in age from 4-7 weeks were used for this study and were grouped into five groups of four rats each. Group one was administered with intramuscular (IM) administration of vitamin E (200mg/kg bw) and undergone testicular torsion with reperfusion for an hour, group two rats had concurrent administration of vitamin E (200mg/kg bw) followed by testicular torsion with reperfusion for an hour, while group three undergone torsion and was treated with vitamin E (200mg/kg bw) after an hour of testicular torsion at 7200 clockwise rotation. Group four undergone testicular torsion for an hour after which detortion was done and reperfusion was allowed for another one hour. While group five served as the control rats. At the end of the experiment testes of all the treated rats were exposed and semen was obtained for sperm characteristics (sperm motility and count). The results showed that following testicular torsion, sperm motility was reduced significantly while sperm count was unaffected. Intramuscular administration of vitamin E following torsion showed insignificant decrease (p>0.05) in sperm function.
Keywords : Reperfusion injury, progressive sperm motility, sperm count, vitamin E, surgery.
Citation : Akintayo C.O, et al (2015), Testicular Torsion Following Reperfusion Injury in Rat Model: Can Vitamin E Palliate this Injury?. J. of Modern Drug Discovery and Drug Delivery Research. V2I4. DOI : 10.5281/zenodo.998895
Copyright : © 2015 Akintayo C.O. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal of Modern Drug Discovery and Drug Delivery Research
ISSN : 2348-3776
Volume 2 / Issue 4
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