Phytochemical Screening, Antibacterial and Antioxidant Activities of Anthocleista liebrechtsiana Wild and T. Durand (Gentianaceae) Originated from Democratic Republic of the Congo
Koto-te-Nyiwa Ngbolua , Rosie Esther N. Mubindukila, Pius T. Mpiana, Damien S.T. Tshibangu, Masengo C. Ashande, Willy-Xavier K. Nzongola, Robijaona Baholy, Pierre Ruphin Fatiany
Corresponding Author : Koto-te-NyiwaNgbolua,
Department of Biology, Faculty of Science, University of Kinshasa, Democratic Republic of the Congo.
Email ID : firstname.lastname@example.org
Received : 2014-05-12 Accepted : 2014-06-02 Published : 2014-06-02
Abstract : Anthocleista liebrechtsiana is a plant species widely used in traditional medicine to treat bacterial infections. To provide a scientific basis to traditional uses of this plant species, it different extracts were evaluated for their antibacterial and antioxidant potential. Antibacterial activity was assessed using minimum inhibitory concentration. The presence of phytoconstituents was detected qualitatively. A. liebrechtsiana extracts displayed interesting antibacterial and antioxidant activities. The Gram positive bacteria S. aureus ATCC 33591 were more sensitive to Anthocleista liebrechtsiana than the Gram negative E. coli ATCC 27195. All the extracts tested were found to be biologically active against Staphyloccocus aureus except alcoholic extract of the leaves for which the bioactivity was moderate. The antibacterial activity was marked for the stem bark extracts (MIC â‰¤ 31.5 Âµg/mL) than those of the leaves (MIC â‰¤ 62.5 Âµg/mL). Methanol extract of A. liebrechtsiana displayed also interesting free radical Scavenging activity (IC50 < 10 Âµg/mL). Phytochemical analysis revealed the presence of total polyphenols, catechic tannins, alkaloids, saponins, terpenes and steroids. Antibacterial and free radical scavenging efficacy shown by this plant provides a scientific basis and thus, validates it traditional use as phytomedicine. Isolation and purification of different phytochemicals may further yield significant antibacterial and antioxidant agents.
Keywords : Traditional medicine, Anthocleista liebrechtsiana, bacterial infections, antioxidant activity, Democratic Republic of the Congo
Citation : Koto-te-Nyiwa Ngbolua, et al (2014). Phytochemical Screening, Antibacterial and Antioxidant Activities of Anthocleista liebrechtsiana Wild & T. Durand (Gentianaceae) Originated from Democratic Republic of the Congo. J. of Advancement in Medical and Life Sciences. V1I3. DOI : 10.5281/zenodo.1000362
Copyright : © 2014 Koto-te-Nyiwa Ngbolua. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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