New Antiplasmodial Derivative from a Structural Modification of Quinuclidin of Quinin
J.N. Molisho, R.T. Kavayita
Corresponding Author : Joseph Ngongo Molisho,
Department of Chemistry, Faculty of Science, University of Kinshasa. P.O. Box 190, DR CONGO.
Email ID : email@example.com
Received : 2015-06-01 Accepted : 2015-07-07 Published : 2015-07-07
Abstract : A new derivative 1 has been synthesized from 6-mÃ©thoxy-4-(1â€™-mÃ©thoxy-2â€™-(8â€™â€™-vinylquinuclidinyl)) quinolin known as quinin . The synthesized compound has been characterized using proton, carbon-13, DEPT-135, 2D-COSY and 2D-HMBC Nuclear Magnetic Resonance data. The evaluation of its in vivo antiplasmodial activities above the NMRI mouses shows that the derivative 1 is most active than its analogue quinin. The derivative 1 shows a parasitemia rate of -0,68% against Plasmodium bergei administered to the NMRI mouses, whereas the parasitemia rate of quinine amount to 0,23% unter the same conditions.
Keywords : Quinin, New derivative, higher in vivo antiplasmodial activities
Citation : J.N. Molisho et al.. (2015) Optimization and Kinetic Studies for the Degradation of Lignin and Chlorophenols by using Rhizopus aarhizus. j. of Physical and Chemical Sciences.V3I2 DOI : 10.5281/zenodo.zenodo.913474
Copyright : © 2015 J.N. Molisho. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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