New Antiplasmodial Derivative from a Structural Modification of Quinuclidin of Quinin
J.N. Molisho, R.T. Kavayita
Corresponding Author : Joseph Ngongo Molisho,
Department of Chemistry, Faculty of Science, University of Kinshasa. P.O. Box 190, DR CONGO.
Email ID : firstname.lastname@example.org
Received : 2015-06-01 Accepted : 2015-07-07 Published : 2015-07-07
Abstract : A new derivative 1 has been synthesized from 6-mÃ©thoxy-4-(1â€™-mÃ©thoxy-2â€™-(8â€™â€™-vinylquinuclidinyl)) quinolin known as quinin . The synthesized compound has been characterized using proton, carbon-13, DEPT-135, 2D-COSY and 2D-HMBC Nuclear Magnetic Resonance data. The evaluation of its in vivo antiplasmodial activities above the NMRI mouses shows that the derivative 1 is most active than its analogue quinin. The derivative 1 shows a parasitemia rate of -0,68% against Plasmodium bergei administered to the NMRI mouses, whereas the parasitemia rate of quinine amount to 0,23% unter the same conditions.
Keywords : Quinin, New derivative, higher in vivo antiplasmodial activities
Citation : J.N. Molisho et al.. (2015) New Antiplasmodial Derivative from a Structural Modification of Quinuclidin of Quinin. j. of Physical and Chemical Sciences.V3I2 DOI : 10.5281/zenodo.zenodo.913474
Copyright : © 2015 J.N. Molisho. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal of Physical and Chemical Sciences
ISSN : 2348-327X
Volume 3 / Issue 2
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