New Antiplasmodial Derivative from a Dimerization of Chloroquinolin radical cations of Amodiaquin
J.N. Molisho, J.K. Sumbu
Corresponding Author : Joseph Ngongo Molisho,
Department of chemistry, Faculty of Science, UniversitÃ© de Kinshasa, B.P.190 Kinshasa XI, DR CONGO.
Email ID : email@example.com
Received : 2016-12-27 Accepted : 2017-02-20 Published : 2017-02-20
Abstract : A new derivative 1 has been synthesized by dimerization of radical cations from 4-[3â€™- diethyl amino methyl-4â€™-hydroxyanilino]-7-Chloroquinolin known as amodiaquin. The synthesized compound has been characterized using proton, carbon-13, 2D-COSY, 2D-HSQC Nuclear Magnetic Resonance data and by Mass spectrometry. The evaluation of its in vivo antiplasmodial activities above The NMRI mouses shows that the derivative 1 is most active than its analogue amodiaquin. The derivative 1 shows a parasitemia rate of 0.20% against Plasmodium bergei administered to the NMRI mouses, whereas the parasitemia rate of amodiaquin amount to 47% under the same conditions. This higher activity of the derivative 1 confirms the pharmacophore character of the chloroquinolin part in the antiplasmodial activity.
Keywords : Amodiaquin, New derivative, higher in vivo antiplasmodial activities
Citation : Joseph Ngongo Molisho et al. (2017). New Antiplasmodial Derivative from a Dimerization of Chloroquinolin radical cations of Amodiaquin, j. of Physical and Chemical Sciences.V4I4. DOI : 10.5281/zenodo.1000318
Copyright : © 2017 Joseph Ngongo Molisho. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal of Physical and Chemical Sciences
ISSN : 2348-327X
Volume 4 / Issue 4
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