New Antiplasmodial Derivative from a Dimerization of Chloroquinolin radical cations of Amodiaquin

Research Article

New Antiplasmodial Derivative from a Dimerization of Chloroquinolin radical cations of Amodiaquin

J.N. Molisho, J.K. Sumbu

Corresponding Author : Joseph Ngongo Molisho,

Department of chemistry, Faculty of Science, Université de Kinshasa, B.P.190 Kinshasa XI, DR CONGO.

Email ID : molishon@yahoo.fr

Received : 2016-12-27 Accepted : 2017-02-20 Published : 2017-02-20

Abstract : A new derivative 1 has been synthesized by dimerization of radical cations from 4-[3’- diethyl amino methyl-4’-hydroxyanilino]-7-Chloroquinolin known as amodiaquin. The synthesized compound has been characterized using proton, carbon-13, 2D-COSY, 2D-HSQC Nuclear Magnetic Resonance data and by Mass spectrometry. The evaluation of its in vivo antiplasmodial activities above The NMRI mouses shows that the derivative 1 is most active than its analogue amodiaquin. The derivative 1 shows a parasitemia rate of 0.20% against Plasmodium bergei administered to the NMRI mouses, whereas the parasitemia rate of amodiaquin amount to 47% under the same conditions. This higher activity of the derivative 1 confirms the pharmacophore character of the chloroquinolin part in the antiplasmodial activity.

Keywords : Amodiaquin, New derivative, higher in vivo antiplasmodial activities

Citation : Joseph Ngongo Molisho et al. (2017). New Antiplasmodial Derivative from a Dimerization of Chloroquinolin radical cations of Amodiaquin, J. of Physical and Chemical Sciences.V4I4.03. DOI : 10.5281/zenodo.1000318

Copyright : © 2017 Joseph Ngongo Molisho. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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