Microwave Assisted Alternate Synthesis Of A Series Of Azomethine Derivatives Of A Semisynthetic Aminopenicillin (Ampicillin)

Research Article

Microwave Assisted Alternate Synthesis Of A Series Of Azomethine Derivatives Of A Semisynthetic Aminopenicillin (Ampicillin)

Abhilash Mullasseril

Corresponding Author : Abhilash Mullasseril,

Mullasseril, veliyanad post., ernakulam dist., kerala-682 313, India.

Email ID : mabhilash@hotmail.com

Received : 2015-05-22 Accepted : 2015-06-28 Published : 2015-06-28

Abstract : The field of synthesis of organic compounds having medicinal importance is in a state of boom developments and it always incorporates different possible methods for achieving the target drugs and similar compounds. All the methods adopted for synthesis of pharmaceuticals must be routed firmly to the green principles in a maximum possible manner. This paper aims the microwave assisted synthesis of a series of azomethine derivatives of widely prescribing semisynthetic penicillin drug called ampicillin. The microwave assisted synthesis of organic compounds is considered as one of the safest among green methods of the synthesis. For the synthesis of azomethines a series of aromatic aldehydes with varying substituent groups and the drug ampicillin trihydrate were irradiated using microwave as the source of energy for the synthesis.

Keywords : Ampicillin; MWAOS; Computer aided Drug designing; Biological activity; Computational methods; Docking

Citation : Abhilash Mullasseril et al (2015), Microwave Assisted Alternate Synthesis Of A Series Of Azomethine Derivatives Of A Semisynthetic Aminopenicillin (Ampicillin). J. of Modern Drug Discovery and Drug Delivery Research. V3I1. DOI : 10.5281/zenodo.999919

Copyright : © 2015 Abhilash Mullasseril. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

ScienceQ Publishing Group

Reviewer Comments :