In vitro Antisickling Activity of Anthocyanins from Ocimum canun (Lamiacea)
D.D. Tshilanda, D.V. Onyamboko, D. T. Mwanangombo1, P.V. Tsalu, N.K. Misengabu, D.S.T. Tshibangu, K.N. Ngbolua, P.T. Mpiana
Corresponding Author : PT Mpiana
Department of Chemistry, Faculty of Science, University of Kinshasa, P.O. Box 190 Kinshasa XI, Democratic Republic of the Congo.
Email ID : email@example.com
Received : 2015-06-02 Accepted : 2015-07-06 Published : 2015-07-06
Abstract : Some medicinal plants used in Congolese traditional medicine in the management of sickle cell disease have showed interesting antisickling activity in vitro. In the present work, antisickling activity of different extracts from Ocimum canum, a medicinal and aromatic plant used in Congolese traditional medicine, was studied. Aqueous, methanolic, ethyl acetate, n-hexane and dichoromethane extracts were tested using Emmelâ€™s test. Polar extract (Aqueous, methanolic, ethyl acetate) showed antisickling activity when non polar (n-hexane and dichoromethane) were inactive. Anthocyanins extracts from O. canun leaves yielded 8.7 % and showed a strong antisickling activity. This biological activity is dose-dependent and reaches a sickle shape normalization rate of 88.5% at a minimal normalization concentration of 15 Âµg/ml.
Keywords : Ocimum canum, anthocyanins, antisickling activity, sickle cell disease, normalization rate
Citation : PT Mpiana et al. (2015). In vitro Antisickling Activity of Anthocyanins from Ocimum canun (Lamiacea).. J. of Advancement in Medical and Life Sciences. V3I2. DOI : 10.5281/zenodo.999940
Copyright : © 2015 PT Mpiana. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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