Histopathological Studies of Physostigma venenosum Balf. on Wistar Rats
Aihiokhai M. O, Idu M, Ovuakporie-Uvo O.
Corresponding Author : Ovuakporie-Uvo O.
Department of Biological Sciences, Faculty of Natural and Applied Sciences, Michael and Cecilia Ibru University, Agbarha-Otor, PMB 100, Ughelli, Delta State, Nigeria.
Email ID : email@example.com
Received : 2019-01-03 Accepted : 2019-02-09 Published : 2019-02-09
Abstract : Physostigma venenosum Balf. seeds which have been implicated for treating diverse ailments were investigated for possible toxicity of the liver in both sexes of Wistar rats. Sixteen Wistar were weighed and divided into four groups of three treatment groups and one control group. Animals were allowed to acclimatize in standard metal cages for 7 days thereafter, fed with graded doses of P. venenosum extract. Group A (control) was administered 10 mg/kg distilled water only, while groups B, C and D were respectively administered with 10, 20 and 30 mg/kg b.w of P. venenosum seed extract of by gastric intubation for 14 days. On day 14, animals in all groups were anaesthetized, their liver were isolated and processed for histopathological studies. Rats treated with 10 mg/kg extracts showed presence of activated kupffer cells, sinusoidal dilatation and moderate vascular congestion, while the groups treated with 20 mg/kg and 30 mg/kg b.w showed mild vascular congestion, mild kupffer cell activation and mild tissue separation, which were significantly different from the control. Histopathological examination suggests that doses higher than 20 mg/kg may possibly induce liver cell injury.
Keywords : Physostigma venenosum (Balf.), Liver, Histopathology
Citation : Ovuakporie-Uvo O et al (2019). Histopathological Studies of Physostigma venenosum Balf. on Wistar Rats. J. of Advanced Botany and Zoology. V7I104. DOI : 10.5281/zenodo.2573795
Copyright : © 2019 Ovuakporie-Uvo O. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal of Advanced Botany and Zoology
ISSN : 2348-7313
Volume 7 / Issue 1
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