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%20%20%20%20Pyrazolone%20Thiosemicarbazone%20Based%20Metal%20Complexes:%20Physico-Chemical%20Study,%20Synthesis%20and%20Biological%20Activity
Research article
  

Pyrazolone Thiosemicarbazone Based Metal Complexes: Physico-Chemical Study, Synthesis and Biological Activity


Rashmi B. Patel, Dhanji P. Rajani, Smita D. Rajani, Hitesh D. Patel

1Department of Chemistry, School of Science, Gujarat University, Ahmedabad-380009, Gujarat, India.
2Microcare Laboratory & TRC, Surat 395003, Gujarat, India


Corresponding author :

Hitesh D. Patel,
Tel.:+91-079-26300969, ,
Email:

Received: June 1, 2015,   Accepted: July 9, 2015,   Published:


Abstract:

In this article we have reported physico-chemical study of 2-((3-methyl -5- oxo -1- phenyl -4,5-dihydro-1H-pyrazol-4-yl)(phenyl)methylene)hydrazinecarbothioamide with various metal ions such as Cu(II), Cr(II), Mn(II), Pd(II), Co(II), Ni(II), Pb(II) and Hg(II) by two methods spectrophotometry and conductometry. The study said that metal:ligand ratio is 1:1 and the further conformation is done by spectral analysis. We have also screened our compounds for antibacterial, antifungal and antimalarial activity.


Keywords: pyrazolone-thioemicarbazone, metal complexes, physico-chemical study, antibacterial, antifungal, antimalarial activity.


Citation:

Hitesh D. Patel et al.. (2015) Pyrazolone Thiosemicarbazone Based Metal Complexes: Physico-Chemical Study, Synthesis and Biological Activity j. of Physical and Chemical Sciences.V3I2. DOI: 10.15297/JPCS.V3I2.03


Copyright:

© 2015 Hitesh D. Patel. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


      
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      Journal of Physical and Chemical Sciences