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%20%20%20%20Synthesis%20of%20ethyl(2Z)-2-(Aryl)-5-(4-chlorophenyl)-7-methyl-3-oxo-2,3,8,8a-tetrahydro-5H%5B1,3%5Dthiazolo%5B3,2-a%5Dpyrimidine-6-carboxylate%20Derivatives%20as%20Biological%20and%20Antifungal%20Active%20Agents
Research article
  

Synthesis of ethyl(2Z)-2-(Aryl)-5-(4-chlorophenyl)-7-methyl-3-oxo-2,3,8,8a-tetrahydro-5H[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate Derivatives as Biological and Antifungal Active Agents


Shital N. Chadotra and B. B. Baldaniya

Chemistry department, M G Science institute, Navarangpura, Ahmedabad-380 009, Gujarat, India.


Shital N. Chadotra,
Email:

Received: January 19, 2017,   Accepted: March 28, 2017,   Published:


Abstract:

The aim of this study was to synthesize several heterocyclic pyrimidine derivatives. Pyrimidine nucleus was synthesized by Pietro Biginelli reaction in past. There are two step reaction was carried out. (1) In first step reaction the derivative synthesized by reaction between ethylacetoacetate, substituted benzaldehyde, and thiourea. (2) In second step reaction give excellent yield of ethyl(2Z)-2-(Aryl)-5-(4-chlorophenyl)-7-methyl-3-oxo-2,3,8,8a-tetrahydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate derivatives (1-13) synthesized by using first reaction derivative, chloro acetic acid, sodium acetate, acetic anhydride, glacial acetic acid with various substituted benzaldehyde. The products have been tested for their antibacterial and antifungal activity against gram (+) positive and gram (-) negative bacteria.


Keywords: 2,3,8,8a-tetrahydro pyrimidine, Biginelli reaction, Antibacterial activity, Antifungal activity.


Citation:

Shital N. Chadotra. et al. (2017). Synthesis of ethyl(2Z)-2-(Aryl)-5-(4-chlorophenyl)-7-methyl-3-oxo-2,3,8,8a-tetrahydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate Derivatives as Biological and Antifungal Active Agents , j. of Physical and Chemical Sciences.V5I1. DOI: 10.15297/JPCS.V5I1.05


Copyright:

© 2017 Shital N. Chadotra. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


      
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      Journal of Physical and Chemical Sciences