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%20%20%20%20Application%20of%20Lanthanide%20Polychelates%20Derived%20from%202,4-dihydroxy%20acetophenone%20Based%20Resin%20as%20Green%20Catalyst%20for%20Biginelli%20Reactions
Research article
  

Application of Lanthanide Polychelates Derived from 2,4-dihydroxy acetophenone Based Resin as Green Catalyst for Biginelli Reactions


Vijay R. Patel, Vijay D. Chavada, Nejal M. Bhatt, Jayantilal D. Joshi , Pranav S. Shrivastav

1. Chemistry Department, Shri R K Parikh Arts & Science College, Petlad-388450, India
2. Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad- 380009, India
3. Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar- 388120, India


Corresponding author :

Pranav S. Shrivastav,
Tel.: +91-079-26300969; Fax: +91-079-26308545,
Email:

Received: January 15, 2015,   Accepted: February 22, 2015,   Published:


Abstract:

In the present study, lanthanide polychelates of 2,4-dihydroxy acetophenone (DHAP) were evaluated for their applicability as green catalyst for various Biginelli reactions. Polymeric resins of DHAP (DHAP-1,2 PD, DHAP-1,3 PD, DHAP-1,3 BD and DHAP-1,4 BD) were synthesized and carried forward for the preparation of their polychelates with lanthanide metal ions viz. La3+, Pr3+, Nd3+, Sm3+, Gd3+, Tb3+ and Dy3+. The polychelates were assessed for their catalytic activity in the preparation of substituted 3,4-dihydropyrimidin-2(1H)-ones, largely known as the Biginelli compounds. In order to study the versatility and provide a comparative evaluation of the polychelates, a number of aldehyde derivatives and substituted 1,3-diketones were used. According to the results obtained, it was summarized that the polychelates possess desired catalytic effect for the aforementioned synthesis. The three component mixture of aldehyde, 1,3-dicarbonyl compound and urea were heated in presence of desired catalytic amount of lanthanide(III) polychelates to give corresponding 3,4-dihydropyrimidin-2(1H)-ones in 87-92 % yield. The reaction was completed within a reaction time of 2-6 h, and the polychelate catalysts could efficiently be reused for several times after simple washing step with distilled water.


Keywords: Phenolic Resin; 2,4-dihydroxyacetophenone; 4-dihydropyrimidin-2(1H)-ones; Polychelates; Lanthanides; Biginelli reaction


Citation:

Pranav S. Shrivastav. et al.. (2015) Application of Lanthanide Polychelates Derived from 2,4-dihydroxy acetophenone Based Resin as Green Catalyst for Biginelli Reactions. j. of Physical and Chemical Sciences.V2I3 DOI: 10.15297/JPCS.V2I3.02


Copyright:

© 2015 Pranav S. Shrivastav. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


      
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      Journal of Physical and Chemical Sciences