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%20%20%20%20Evaluation%20of%20a%20Novel,%20Natural%20Locust%20Bean%20Gum%20as%20a%20Sustained%20Release%20and%20Mucoadhesive%20Component%20of%20Tizanidine%20Hcl%20Buccal%20Tablets
Research article
  

Evaluation of a Novel, Natural Locust Bean Gum as a Sustained Release and Mucoadhesive Component of Tizanidine Hcl Buccal Tablets


Harikrishnan.V, S.Madhusudhan , A. Santhiagu

1 Assistant Professor, Department of Pharmaceutics, National College Of Pharmacy, Kerala. India.
2 Assistant Professor, Department of Pharmacy, Annamalai University, Tamil Nadu. India.
3 Associate Professor, School of Biotechnology, NIT Calicut, Kerala.India.


Corresponding author :

Harikrishnan.V,
Email:

Received: June 28, 2015,   Accepted: August 8, 2015,   Published:


Abstract:

Mucoadhesive polymers that bind to the gastric mucin or epithelial cell surface are useful in drug delivery for the purpose of increasing the intimacy and duration of contact of drug with the absorbing membrane. Mainly synthetic polymers are in use for this purpose. Probably the biodegradability of the synthetic polymers are questionable, In the present work mucoadhesive buccal tablets of Tizanidine hydrochloride (TZD HCl) were prepared by using locust bean gum that have better mucoadhesive property than synthetic polymer. The in-vitro adhesive and mucoadhesive strength and swelling property of mucoadhesive material locust bean gum were evaluated by Share Stress and Park and Robinson methods. Buccal formulations of tizanidine HCL tablets were prepared using locust bean gum and thickness, hardness, friability, weight variation and assay of tablets were tested. The in-vitro drug release study of tizanidine HCL exhibited extended drug release profile for tablets prepared. Higuchi and Peppas data reveals that the drug released by non-Fickian diffusion mechanism. The present study shows that formulation containing 50% locust bean gum have greater mucoadhesive property than all other formulation.


Keywords: Mucoadhesive, Tizanidine HCL, and tablets. bioadhesive


Citation:

Harikrishnan.V et al (2015), Evaluation of a Novel, Natural Locust Bean Gum as a Sustained Release and Mucoadhesive Component of Tizanidine Hcl Buccal Tablets. J. of Modern Drug Discovery and Drug Delivery Research. V3I2. DOI: 10.15297/JMDDR.V3I2.01


Copyright:

© 2015 Harikrishnan.V. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


      
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      Journal of Modern Drug Discovery and Drug Delivery Research