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Synthesis%20of%20several%202-(5-chloro-3-methyl-1-(pyridin-2-yl)%20pyrazolidin-4-yl)-3-%20substituted%20phenylthiazolidin-4-ones%20as%20prospective%20antimicrobial%20agents
Research article
  

Synthesis of several 2-(5-chloro-3-methyl-1-(pyridin-2-yl) pyrazolidin-4-yl)-3- substituted phenylthiazolidin-4-ones as prospective antimicrobial agents


Ranjana Dubey, Nidhi Chaudhary, Hament Panwar

1. Department of Chemistry, S.R.M. University, U.P., India
2. Department of Chemistry, M.I.E.T., U.P., India
3. Department of Chemistry, Neelkanth Institute of Technology, U.P., India


Corresponding author :

Hament Panwar,
Department of Chemistry,
Neelkanth Institute of Technology,
Modipuram-250110, Meerut, U.P., India.

Received: December 26, 2013,   Accepted: December 28, 2013,   Published:


Abstract:

Several 2-(5- chloro-3- methyl-1- (pyridin-2-yl) pyrazolidin-4-yl)-3- substitutedphenylthiazolidin -4-one (4a-f) have been synthesized by conventional synthesis methodology. The synthesized derivatives were characterized by IR, 1H-NMR, Mass and elemental analysis (C, H, N) . Furthermore the synthesized 2-(5-chloro-3-methyl-1-(pyridin-2-yl) pyrazolidin-4-yl)-3- substitutedphenylthiazolidin-4-one (4a-f) were tested for antimicrobial activities. The compound 4c displayed significant biological activities among the all tested derivatives.


Keywords: Antibacterial, antifungal, thiazolidin-4-one, acute toxicity.


Citation:

Hament Panwar(2013). Synthesis of several 2-(5-chloro-3-methyl-1-(pyridin-2-yl) pyrazolidin-4-yl)-3- substitutedphenylthiazolidin-4-ones as prospective antimicrobial agents. J. of Modern Drug Discovery And Drug Delivery Research. V1I1. DOI: 10.15297/JMDDR.V1I1.01


Copyright: © 2013 Hament Panwar, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


      
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      Journal of Modern Drug Discovery and Drug Delivery Research