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Design%20and%20In%20Vitro%20Evaluation%20of%20Benzydamine%20Hydrochloride%20Effervescent%20Tablets%20for%20Vaginal%20Delivery
Research article
  

Design and In Vitro Evaluation of Benzydamine Hydrochloride Effervescent Tablets for Vaginal Delivery


Ambikar R. B., Powar P. V., deokar G. S, Sharma P. H.

1. Padmashree Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-411044, India.
2. Department of Pharmaceutics, Bhujbal Knowledge City, Institute of Pharmacy, Nashik, India.


Corresponding author :

Ambikar R. B.
Padmashree Dr. D. Y. Patil College of Pharmacy,
Akurdi, Pune-411044, India.
Email:

Received: January 10, 2014,   Accepted: January 23, 2014,   Published:


Abstract:

Benzydamine hydrochloride (BEN) has immediate action on vaginal inflammation, also has an activity against Trichomonas vaginalis and Gardnerella vaginalis. Of vaginal dosage forms, patients are known to better tolerate gels. However, the direct application of gels onto the infected sites of the vagina might be difficult, inconvenient as well as need frequent dosing. Effervescent vaginal tablets offer convenience of dosing methods of tablet and disintegrate rapidly to prevent vaginal clearance due to gravity. Sodium bicarbonate and citric acid were added as effervescent mixture, to increase disintegration time of the tablet; Lactose as diluents; sodium lauryl sulphate as foaming agent and starch as disintegrant. Three formulations (F1, F2, and F3) were prepared by varying concentration of starch. Tablets were evaluated for hardness, disintegration time, friability, dissolution profile and effect on pH value of medium. F1 shows maximum disintegration time approximately 20 minutes, F2 and F3 shows 15 minutes and 11 minutes respectively. Dissolution profile of F1 shows 74.48% release, F2 and F3 shows 78.89% and 99.94% release within 8 minutes respectively, thus F3 formulation shows nearly complete release within 8 minutes and lower disintegration time. Formulations showed pH change of the medium within normal range of vaginal fluid (pH 3.2-4.8). Effervescent vaginal tablet will surely enhance patient compliance.


Keywords: Benzydamine, effervescent vaginal tablet, vaginitis.


Citation:

Ambikar R. B.(2014) Design and In Vitro Evaluation of Benzydamine Hydrochloride Effervescent Tablets for Vaginal Delivery. J. of Modern Drug Discovery And Drug Delivery Research. V1I1. DOI: 10.15297/JMDDR.V1I1.03


Copyright:

© 2014 Ambikar R. B., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


      
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      Journal of Modern Drug Discovery and Drug Delivery Research