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%20%20%20%20Canarium%20schweinfurthii%20Engl.%20(Burseraceae):%20An%20Updated%20Review%20and%20Future%20Direction%20for%20Sickle%20Cell%20Disease
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Canarium schweinfurthii Engl. (Burseraceae): An Updated Review and Future Direction for Sickle Cell Disease


Koto-te-Nyiwa Ngbolua, Lengbiye E. Moke, Joseph K. Lumande, Pius T. Mpiana

1Department of Biology, Faculty of Science, University of Kinshasa, P.O. Box 190 Kinshasa XI, Democratic Republic of the Congo
2Department of Chemistry, Faculty of Science, University of Kinshasa, P.O. Box 190 Kinshasa XI, Democratic Republic of the Congo


Corresponding author :

Prof. Dr. Koto-te-Nyiwa Ngbolua,
Email:

Received: September 19, 2015,   Accepted: October 30, 2015,   Published:


Abstract:

The aim of the study was to collect data obtained from various studies carried out by different authors concerning the phytochemistry and pharmacology of Canarium schweinfurthii. This review has been compiled using references from major databases such as PubMed, PubMed Central, ScienceDirect and Google scholars Databases. An extensive survey of literature revealed that C. schweinfurthii is a good source of health promoting secondary metabolites such as phenolic and terpenoic acids among others that could have many wonderful applications (like antisickling properties). The plant has been reported to possess several pharmacological activities such as analgesic, antimicrobial and antioxidant, anti-diabetic and anti-inflammatory activities. The plant is also belongs to the great apes (GA) feeding. Humans and great apes (bonobos, chimpanzees, gorillas, etc.) share a common gut anatomy. Although, some diseases that cause countless deaths in humans (like malaria) are ineffective or have minor non disturbing effects in GA. They represent therefore a good model for human pathology and physiology. This GA plant based food could protect human sickle erythrocyte against hemolysis by inhibiting the polymerization of sickle hemoglobin and radical oxygen species formation within sickle erythrocyte as it does for Plasmodium falciparum infected erythrocytes in bonobos. The results of the present review of literature makes C. schweinfurthii an interesting candidate for advanced antisickling pharmacological investigations such as antisickling, anti-hemolytic and membrane stabilizing effects of this plant.


Keywords: Sickle cell Disease, ethno-pharmacology, zoopharmacognosy, chemotaxonomy, Canarium schweinfurthii


Citation:

Koto-te-Nyiwa Ngbolua et al. (2015). Canarium schweinfurthii Engl. (Burseraceae): An Updated Review and Future Direction for Sickle Cell Disease. J. of Advancement in Medical and Life Sciences. V3I3 DOI: 10.15297/JALS.V3I3.05


Copyright:

© 2015 Koto-te-Nyiwa Ngbolua. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


      
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      Journal of Advancement in Medical and Life Sciences