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%20%20%20%20An%20In-Vitro%20Assessment%20of%20Antimicrobial,%20Thrombolytic%20and%20Cytotoxic%20Activity%20on%20Ipomoea%20Pes-Tigridis
Research article
  

An In-Vitro Assessment of Antimicrobial, Thrombolytic and Cytotoxic Activity on Ipomoea Pes-Tigridis


Md Rabiul Hossain chowdhury, Rocky Saha, Md Iqbalkaiser Bhuiyan, Md. Amzad Hossain, Sheikh Anas Mohammad Kowsar, Mir Monir Hossain

1. Department of Pharmacy, University of Science & Technology Chittagong, Chittagong, Bangladesh.
2. Department of Genetic Engineering & Biotechnology, University of Chittagong, Bangladesh.


Corresponding author :

Md Rabiul Hossain Chowdhury,
Tel : +880-01672278090,
Email:

Received: October 12, 2014,   Accepted: November 8, 2014,   Published:


Abstract:

To explore activities antimicrobial, thrombolytic, cytotoxic of the ethyl acetate extract and n-hexane extract of Ipomoea pes-tigridis leaves. Antimicrobial study was measured by noticing zone of inhibition. In vitro thrombolytic activity by clot lysis method and cytotoxic activity was considered by using brine shrimp lethality bioassay.Anti-microbiological screening ethyl acetate extract of leaves showed mild antimicrobial activity with zone of inhibition ranging from 11 to 14 mm and n hexane also showed mild antimicrobial activity with zone of inhibition ranging from 4 to 9 mm as compared to standard ciprofloxacin (zone of inhibition of 50 mm). In vitro thrombolytic model was applied to find out the clot lysis effect of ethyl acetate and n-hexane extracts of Ipomoea pes-tigridis where streptokinase and water were employed as a positive and negative controls, respectively. The extracts showed thrombolytic activity 14.90% and 8.18%. In Brine Shrimp Lethality Bioassay, ethyl acetate extract of Ipomoea pes-tigridis exhibited LC50 at 14.125μg/ml and n hexane extract of Ipomoea pes-tigridis exhibited LC50 at 33.113μg/ml and which showed that the extract is pharmacologically dynamic. Investigation disclosed that the plant is pharmacologically active and it possesses mild antimicrobial activity, thrombolytic activity as well as remarkable cytotoxic effect. Thus , this plant can be a good source of some useful drugs of therapeutic.


Keywords: Antimicrobial, Thrombolytic, Cytotoxic, Ipomoea pes-tigridis.


Citation:

Md Rabiul Hossain Chowdhury, et al. (2014). An In-Vitro Assessment of Antimicrobial, Thrombolytic and Cytotoxic Activity on Ipomoea Pes-Tigridis. J. of Advancement in Medical and Life Sciences. V2I2. DOI: 10.5281/zenodo.1000336


Copyright:

© 2014 Md Rabiul Hossain Chowdhury. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


      
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      Journal of Advancement in Medical and Life Sciences