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%20%20%20%20Evaluation%20of%20the%20Vasorelaxant%20Effect%20Induced%20by%20the%20Essential%20Oil%20Extracted%20from%20the%20Root%20Bark%20of%20Hazumalania%20voyronii%20(Jum.)%20Capuron%20(Hernandiaceae)%20in%20Wistar%20Rat%20Aorta%20Ring
Research article
  

Evaluation of the Vasorelaxant Effect Induced by the Essential Oil Extracted from the Root Bark of Hazumalania voyronii (Jum.) Capuron (Hernandiaceae) in Wistar Rat Aorta Ring


Robijaona Baholy, Fatiany Pierre Ruphin, Koto –te- Nyiwa Ngbolua, Fiatoa Barthelemy, Raharisololalao Amélie, Rakotomamonjy Pierre, Moulis Claude, Virima Mudogo, Pius T. Mpiana, Rakotondramanana Samuel, Razakarivelo Robin Miadana

1 Malagasy Institute of Applied Research, Avarabohitra Itaosy lot AVB 77, P.O. Box 3833, 102 Antananarivo, Madagascar
2Department of Chemical Engineering, Polytechnic High School, P.O. Box 1500, University of Antananarivo, 101 Antananarivo, Madagascar
3Department of Organic Chemistry, Faculty of Science, P.O. Box 187, University of Toliara, 601 Toliara, Madagascar
4Faculty of Science, University of Kinshasa, P.O. Box 190 Kinshasa XI, Democratic Republic of the Congo
5Department of Organic Chemistry, Faculty of Science, P.O. Box 906 University of Antananarivo, 101 Antananarivo, Madagascar.
6Pharmacognosy Laboratory, Faculty of Pharmaceutical Sciences, 35 Chemin des Maraîchers, Cedex 4, 31062 Toulouse, France
7Antananarivo Drugs Agency, Madagascar


Corresponding author :

Associate Professor Koto-te-Nyiwa Ngbolua,
Tel: +243 81 68 79 527,
Email:

Received: September 18, 2014,   Accepted: October 28, 2014,   Published:


Abstract:

The present was carried out with the aim to investigate the vasorelaxant effect induced by essential oil extracted from the root bark of Hazumalania voyronii in order to validate its use scientifically in Malagasy folk medicine. The vasorelaxant activity of the essential oil was carried out using an ex vivo method based on the rat aortic rings pre-contracted with phenylephrine. Rings of rat aorta were suspended in organ bath containing Krebs solution at 37 °C. Isometric contractions were measured using a force transducer coupled to an amplifier. Essential oil induces concentration-dependent relaxation in pre-contracted aortic rings (EC50 = 160.87 ± 7 µg/ml; Emax = 91.13 ± 3.2%). This result indicates that Hazumalania voyronii essential oil (EOIH) possesses vasorelaxant activity on the isolated organs. The ability of EOIH to display vasorelaxant activity supports the use of this plant species as medicine by the traditional healers in Madagascar. However, further studies are necessary to evaluate better its safety and therapeutic margin before the wide use of the plant oil.


Keywords: Traditional medicine, Madagascar, Hazumalania voyronii, vasorelaxant activity, aortic ring, Wistar rat


Citation:

Koto-te-Nyiwa Ngbolua., et al. (2014). Evaluation of the Vasorelaxant Effect Induced by the Essential Oil Extracted from the Root Bark of Hazumalania voyronii (Jum.) Capuron (Hernandiaceae) in Wistar Rat Aorta Ring. J. of Advancement in Medical and Life Sciences. V2I1. DOI: 10.15297/JALS.V2I1.04


Copyright:

© 2014 Koto-te-Nyiwa Ngbolua. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


      
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      Journal of Advancement in Medical and Life Sciences