Application of Lanthanide Polychelates Derived from 2,4-dihydroxy acetophenone Based Resin as Green Catalyst for Biginelli Reactions
Vijay R. Patel, Vijay D. Chavada, Nejal M. Bhatt, Jayantilal D. Joshi , Pranav S. Shrivastav
Corresponding Author : Pranav S. Shrivastav,
Chemistry Department, Shri R K Parikh Arts & Science College, Petlad-388450, India
Email ID : email@example.com
Received : 2015-01-15 Accepted : 2015-02-23 Published : 2015-02-23
Abstract : In the present study, lanthanide polychelates of 2,4-dihydroxy acetophenone (DHAP) were evaluated for their applicability as green catalyst for various Biginelli reactions. Polymeric resins of DHAP (DHAP-1,2 PD, DHAP-1,3 PD, DHAP-1,3 BD and DHAP-1,4 BD) were synthesized and carried forward for the preparation of their polychelates with lanthanide metal ions viz. La3+, Pr3+, Nd3+, Sm3+, Gd3+, Tb3+ and Dy3+. The polychelates were assessed for their catalytic activity in the preparation of substituted 3,4-dihydropyrimidin-2(1H)-ones, largely known as the Biginelli compounds. In order to study the versatility and provide a comparative evaluation of the polychelates, a number of aldehyde derivatives and substituted 1,3-diketones were used. According to the results obtained, it was summarized that the polychelates possess desired catalytic effect for the aforementioned synthesis. The three component mixture of aldehyde, 1,3-dicarbonyl compound and urea were heated in presence of desired catalytic amount of lanthanide(III) polychelates to give corresponding 3,4-dihydropyrimidin-2(1H)-ones in 87-92 % yield. The reaction was completed within a reaction time of 2-6 h, and the polychelate catalysts could efficiently be reused for several times after simple washing step with distilled water.
Keywords : Phenolic Resin; 2,4-dihydroxyacetophenone; 4-dihydropyrimidin-2(1H)-ones; Polychelates; Lanthanides; Biginelli reaction
Citation : Pranav S. Shrivastav. et al.. (2015) Application of Lanthanide Polychelates Derived from 2,4-dihydroxy acetophenone Based Resin as Green Catalyst for Biginelli Reactions. j. of Physical and Chemical Sciences.V2I3 DOI : 10.5281/zenodo.890388
Copyright : Â© 2015 Pranav S. Shrivastav. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal of Physical and Chemical Sciences
ISSN : 2348-327X
Volume 2 / Issue 3
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