Antisickling, antihemolytic and radical scavenging activities of essential oil from Entandrophragma Cylindricum (Sprague) Sprague (Meliaceae)

Research Article

Antisickling, antihemolytic and radical scavenging activities of essential oil from Entandrophragma Cylindricum (Sprague) Sprague (Meliaceae)

J.P. Mbula, J.T.K. Kwembe, D.D. Tshilanda, K.N. Ngbolua, O.N. Kabena, S.M. Nsimba, O. Onautshu , P.T. Mpiana

Corresponding Author : P.T. Mpiana

Faculty of Sciences, University of Kinshasa, B.P. 190 Kinshasa XI, D R Congo.

Email ID : ptmpiana@gmail.com

Received : 2018-01-12 Accepted : 2018-02-05 Published : 2018-02-05

Abstract : Essential oil of Entandrophragma Cylindricum from Masoko forest (Tshopo province, DR Congo) was extracted and tested for antisickling, antihemolytic and radical scavenging activities. The obtained results indicate that the extraction gives a yield of 0.85% of essential oil with a density of 0.8581 and refractive index of 1.5025 at 20°C. The essential oil showed a good antisickling activity comparatively to methanolic and aqueous extracts of the same plant with a maximal rate of red blood cells normalization of 89% and minimal concentration of normalization 80 µL/mL. When methanolic and aqueous have maximal rate of normalization of only 24 and 33 % respectively. The essential oil showed also the highest antihemolytic effect and a good radical scavenging effect.

Keywords : Entandrophragma Cylindricum, antisickling, antihemolitic, radical scavenging activity, normalization rate

Citation : P.T. Mpiana et al. (2018). Antisickling, antihemolytic and radical scavenging activities of essential oil from Entandrophragma Cylindricum (Sprague) Sprague (Meliaceae). J. of Advancement in Medical and Life Sciences. V6I2-03. DOI : 10.5281/zenodo.1167931

Copyright : © 2018 P.T. Mpiana. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

ScienceQ Publishing Group

Download Article