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New Antiplasmodial Derivative from a Structural Modification of Quinuclidin of Quinin
Research article
  

New Antiplasmodial Derivative from a Structural Modification of Quinuclidin of Quinin


J.N. Molisho, R.T. Kavayita

1. Département of chimie, Faculté des Sciences,Université de Kinshasa,B.P.190 Kinshasa XI, DR CONGO


Corresponding author :

Joseph Ngongo Molisho,
Tel.: +243-812338094,
Email:

Received: June 1, 2015,   Accepted: July 7, 2015,   Published:


Abstract:

A new derivative 1 has been synthesized from 6-méthoxy-4-(1’-méthoxy-2’-(8’’-vinylquinuclidinyl)) quinolin known as quinin . The synthesized compound has been characterized using proton, carbon-13, DEPT-135, 2D-COSY and 2D-HMBC Nuclear Magnetic Resonance data. The evaluation of its in vivo antiplasmodial activities above the NMRI mouses shows that the derivative 1 is most active than its analogue quinin. The derivative 1 shows a parasitemia rate of -0,68% against Plasmodium bergei administered to the NMRI mouses, whereas the parasitemia rate of quinine amount to 0,23% unter the same conditions.


Keywords: Quinin, New derivative, higher in vivo antiplasmodial activities


Citation:

J.N. Molisho et al.. (2015) Optimization and Kinetic Studies for the Degradation of Lignin and Chlorophenols by using Rhizopus aarhizus. j. of Physical and Chemical Sciences.V3I2 DOI: 10.15297/JPCS.V3I2.01


Copyright:

© 2015 J.N. Molisho. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


      
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      Journal of Physical and Chemical Sciences