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New Antiplasmodial Derivative from a Dimerization of Chloroquinolin radical cations of Amodiaquin
Research article
  

New Antiplasmodial Derivative from a Dimerization of Chloroquinolin radical cations of Amodiaquin


J.N. Molisho, J.K. Sumbu

Department of chemistry, Faculty of Science, Université de Kinshasa, B.P.190 Kinshasa XI, DR CONGO


Corresponding author :

Joseph Ngongo Molisho,
Tel.: +243-812338094,
Email:

Received: December 27, 2016,   Accepted: December 27, 2016,   Published:


Abstract:

A new derivative 1 has been synthesized by dimerization of radical cations from 4-[3’- diethyl amino methyl-4’-hydroxyanilino]-7-Chloroquinolin known as amodiaquin. The synthesized compound has been characterized using proton, carbon-13, 2D-COSY, 2D-HSQC Nuclear Magnetic Resonance data and by Mass spectrometry. The evaluation of its in vivo antiplasmodial activities above The NMRI mouses shows that the derivative 1 is most active than its analogue amodiaquin. The derivative 1 shows a parasitemia rate of 0.20% against Plasmodium bergei administered to the NMRI mouses, whereas the parasitemia rate of amodiaquin amount to 47% under the same conditions. This higher activity of the derivative 1 confirms the pharmacophore character of the chloroquinolin part in the antiplasmodial activity.


Keywords: Amodiaquin, New derivative, higher in vivo antiplasmodial activities


Citation:

Joseph Ngongo Molisho et al. (2017). New Antiplasmodial Derivative from a Dimerization of Chloroquinolin radical cations of Amodiaquin, j. of Physical and Chemical Sciences.V4I4. DOI: 10.15297/JPCS.V4I4.01


Copyright:

© 2017 Joseph Ngongo Molisho. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


             
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      Journal of Physical and Chemical Sciences
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      Journal of Physical and Chemical Sciences