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In vitro and in vivo anti-malarial and cytotoxic activities of ethanolic extracts of Annona senegalensis Pers (Annonaceae) from Democratic Republic of the Congo
Research article
  

In vitro and in vivo anti-malarial and cytotoxic activities of ethanolic extracts of Annona senegalensis Pers (Annonaceae) from Democratic Republic of the Congo


Koto-te-Nyiwa Ngbolua, Virima Mudogo, Pius T. Mpiana, Damien S.T. Tshibangu, Dorothee D. Tshilanda, Masengo C. Ashande

1. Cell & Molecular Biology and Biochemistry of pathogenic Organisms Unit, Department of Biology, Faculty of Science, University of Kinshasa, P.O. Box 190 Kinshasa XI, Democratic Republic of the Congo.
2. Natural products and Medicinal chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Kinshasa, P.O. Box 190 Kinshasa XI, Democratic Republic of the Congo.
3. Scientific Committee for Research, Conservation and the Development of Biodiversity, Faculty of Science, University of Kinshasa, D.R. Congo


Corresponding author :

Koto-te-Nyiwa Ngbolua,
Tel: (+243) 81 68 79 527),
Email:

Received: November 12, 2014,   Accepted: December 26, 2014,   Published:


Abstract:

The objective of this study was to validate scientifically the antimalarial effectiveness and safety of A. senegalensis. Ethanolic crude extracts of Annona senegalensis growing in Democratic Republic of the Congo were evaluated for the inhibitory effects on two malaria parasites strains (P. falciparum FcM29 & P. yoelii subsp nigeriensis) and cytotoxicity towards leukaemia P-388 cell lines. Results indicate that, the antiplasmodial activities of tested plant extracts are moderate in vitro and weak in vivo. While the leaves crude extract displayed toxic effect towards P-388 cells. So, the wide use of this medicinal plant in Congolese Folk Medicine as antimalarial herbal could constitutes a great risk of population poisoning.


Keywords: Malaria, Traditional Medicine, cytotoxicity, Democratic Republic of the Congo.


Citation:

Koto-te-Nyiwa Ngbolua, et al (2014), In vitro and in vivo anti-malarial and cytotoxic activities of ethanolic extracts of Annona senegalensis Pers (Annonaceae) from Democratic Republic of the Congo. J. of Modern Drug Discovery and Drug Delivery Research. V2I2. DOI: 10.15297/JMDDR.V2I2.01


Copyright:

© 2014 Koto-te-Nyiwa Ngbolua. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


      
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      Journal of Modern Drug Discovery and Drug Delivery Research