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Drepanoalpha: An Overview on the Quality Control Process and Standardization Feature of an Antisickling Herbal Drug from Democratic Republic of the Congo
Research article
  

Drepanoalpha: An Overview on the Quality Control Process and Standardization Feature of an Antisickling Herbal Drug from Democratic Republic of the Congo


Koto-te-Nyiwa Ngbolua, Joseph D. Tshidibi, Damien S.T. Tshibangu, Patrick B. Memvanga, Zoawe B. Gbolo, Dorothée D. Tshilanda, Pius T. Mpiana

1Department of Biology, Faculty of Science, University of Kinshasa, P.O. Box 190 Kinshasa XI, Democratic Republic of the Congo
2Department of Chemistry, Faculty of Science, University of Kinshasa, P.O. Box 190 Kinshasa XI, Democratic Republic of the Congo
3Faculty of Pharmaceutical Sciences, University of Kinshasa, P.O. Box 212 Kinshasa XI, Democratic Republic of the Congo


Corresponding author :

Prof. Koto-te-Nyiwa Ngbolua (PhD),
Tel.: +243 81 68 79 527 ,
Email:

Received: December 8, 2015,   Accepted: January 25, 2016,   Published:


Abstract:

Sickle cell disease (SCD) is an autosomal recessive type of hemoglobin disorder. Nowadays, the main challenge is how to improve the clinical aspects of life quality of the patients with low toxicity and safer therapy from indigenous knowledge. Democratic Republic of the Congo is one of the biodiversity rich countries in the world and can play the lead role in production and commercialization of standardized antisickling formulations like Drepanoalpha® worldwide. In this research paper, various methods of phytochemical standardization, such as TLC, HPTLC, HPLC, UV-Vis, IR, MS and their hyphenated techniques for profiling and quantification of markers compounds like phenolics (anthocyanins, flavonoids), phenolic and/or triterpenoic acids in Drepanoalpha®, a polyherbal medicine produced through a bio-guided based plant selection after eight years of intensive advanced laboratory research, are proposed for quality control and standardization feature.


Keywords: Sickle cell disease, Traditional Medicine, Medicinal plants, Drepanoalpha®, standardization, Democratic Republic of the Congo


Citation:

Koto-te-Nyiwa Ngbolua et al (2016), Drepanoalpha®: An Overview on the Quality Control Process and Standardization Feature of an Antisickling Herbal Drug from Democratic Republic of the Congo. J. of Modern Drug Discovery and Drug Delivery Research. V4I1 DOI: 10.15297/JMDDR.V4I1.01


Copyright:

© 2016 Koto-te-Nyiwa Ngbolua. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


      
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      Journal of Modern Drug Discovery and Drug Delivery Research