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An Overall Review on Colon Specific Drug Delivery System
Review
  

An Overall Review on Colon Specific Drug Delivery System


A. Krishna sailaja*, B.Tejaswi

RBVRR College of Pharmacy


Corresponding author :

A. Krishna sailaja,
Associate Professor,
RBVRR College of Pharmacy,
Hyderabad, India.

Received: December 30, 2013,   Accepted: January 6, 2014,   Published:


Abstract:

Numerous drug entities based on oral delivery have been successfully commercialized, but many others are not readily available by oral administration, because they are incompatible with the physical and chemical environments of the upper gastrointestinal tract (GIT) and demonstrate poor uptake in the upper GI tract. Due to the lack of digestive enzymes, colon is considered as suitable site for the absorption of various drugs. Over the past two decades the major challenge for scientist is to target the drugs specifically to the colonic region of GIT. Previously colon was considered as an innocuous organ solely responsible for absorption of water, electrolytes & temporary storage of stools. But now it is accepted as important site for drug delivery. In this review we focused on different approaches for colonic delivery and major applications of colonic drug delivery system.


Citation:

A. Krishna sailaja(2013) An Overall Review on Colon Specific Drug Delivery System. J. of Modern Drug Discovery And Drug Delivery Research. V1I1. DOI: 10.15297/JMDDR.V1I1.02


Copyright:

© 2013 A. Krishna sailaja, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


      
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      Journal of Modern Drug Discovery and Drug Delivery Research