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The Possible Role of a Congolese polyherbal formula (Drepanoalpha) as source of Epigenetic Modulators in Sickle Cell Disease: A Hypothesis
Research article
  

The Possible Role of a Congolese polyherbal formula (Drepanoalpha) as source of Epigenetic Modulators in Sickle Cell Disease: A Hypothesis


Koto-te-Nyiwa Ngbolua, Pius Tshimankinda Mpiana

Department of Biology, Faculty of Science, University of Kinshasa,


Corresponding author :

Associate Professor. Koto-te-Nyiwa Ngbolua,
Tel.: +243 81 68 79 527,
Email:

Received: September 8, 2014,   Accepted: October 10, 2014,   Published:


Abstract:

The core message of the present paper is to show how we did to transform indigenous data (Traditional Medicine) into knowledge (Science), and then translate knowledge into innovation. The anti-sickle cell anemia activity of Drepanoalpha® could be due to its epigenetic modulator effect as revealed by the testimony’s of all patients received the product. Drepanoalpha® reduces the frequency of their crises and improves their general state and their hemoglobin level. All the treated patients have normal phenotype if compared them to normal individuals and have not made any more crises for more than six months last. Anthocyanins which are the biologically active secondary metabolites of this polyherbal formula are well known in the literature for their impact on epigenetic regulation.


Keywords: Sickle cell disease, Phytomedicine, Drepanoalpha®, epigenetic modulation


Citation:

Koto-te-Nyiwa Ngbolua, et al. (2014). The Possible Role of a Congolese polyherbal formula (Drepanoalpha) as source of Epigenetic Modulators in Sickle Cell Disease: A Hypothesis. J. of Advancement in Medical and Life Sciences. V2I1. DOI: 10.15297/JALS.V2I1.02


Copyright:

© 2014 Koto-te-Nyiwa Ngbolua. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


      
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      Journal of Advancement in Medical and Life Sciences