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The Study on the Antifungal Activities of Novel Derivatives of Indole, Benzofuran and Dihydropyrimidine against Candida, Aspergillus and Dermatophytes Species by Broth Micro-Dilution Method
Research article
  

The Study on the Antifungal Activities of Novel Derivatives of Indole, Benzofuran and Dihydropyrimidine against Candida, Aspergillus and Dermatophytes Species by Broth Micro-Dilution Method


Kamiar Zomorodian, Hamid Reza Safaei, Sahar Mousapour, Keyvan Pakshir, Saeed Mousapour, Niusha Safaei, Seyed Ali Jehbez

1Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Applied Chemistry, Faculty of Science, Shiraz Branch, Islamic Azad University, P.O. Box 71993-5, Shiraz, Iran
3Department of Medical Mycology and Parasitology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4Department of Chemistry, Faculty of Basic Science, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
5Department of IT, Computer Science and Engineering, School of Electrical and Computer Engineering, Shiraz University, Shiraz, Iran


Corresponding author :

Hamid Reza Safaei,
Email:

Received: April 25, 2016,   Accepted: July 11, 2016,   Published:


Abstract:

Antifungal drugs are one of the medicines group that have the most increasing use in the past few years in human medicine sciences, especially with the development of AIDS epidemic and immunosuppressed diseases. In this line researchers have concentrated the development of new antifungal drugs that have less toxicity and more effective. The aims of this study are synthesis a few numbers of new derivatives of indole, benzofuran and dihydropyrimidine and all these products were evaluated for in vitro evaluation antifungal activity against various species of Candida, Aspergillus, and Dermatophyte by Broth Microdilution method. They also were investigated against exophiala dermatitidis, Pseudallescheria boydii, Penicillium marneffei, Cryptococcus neoformans and several species of bacteria, including Staphylococcus aureus, Escherichia coli, and Enterobacter faecalis. The obtained results were shown that some of them had outstanding effects. This research have also revealed that among the various synthesised compounds with different Structures, benzofuran derivatives were shown the best antifungal activities, while the indole and dihydropyrimidine analogues had no significant antifungal effect.


Keywords: Indole, benzofuran, dihydropyrimidine, antifungal and antimicrobial activity, broth micro dilution method.


Citation:

Hamid Reza Safaei et al. (2016). The Study on the Antifungal Activities of Novel Derivatives of Indole, Benzofuran and Dihydropyrimidine against Candida, Aspergillus and Dermatophytes Species by Broth Micro-Dilution Method. J. of Advancement in Medical and Life Sciences. V4I4. DOI: 10.15297/JALS.V4I4.01


Copyright:

© 2016 Hamid Reza Safaei. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


      
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      Journal of Advancement in Medical and Life Sciences