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In vitro Antisickling Activity of Anthocyanins from Ocimum canun (Lamiacea)
Research article
  

In vitro Antisickling Activity of Anthocyanins from Ocimum canun (Lamiacea)


D.D. Tshilanda, D.V. Onyamboko, D. T. Mwanangombo1, P.V. Tsalu, N.K. Misengabu, D.S.T. Tshibangu, K.N. Ngbolua, P.T. Mpiana

1Department of Chemistry, Faculty of Science, University of Kinshasa, P.O. Box 190 Kinshasa XI, Democratic Republic of the Congo
2Institut de Recherche en Sciences de la Santé IRSS, Kinshasa, Democratic Republic of the Congo
3Department of Biology, Faculty of Science, University of Kinshasa, P.O. Box 190 Kinshasa XI, Democratic Republic of the Congo.


Corresponding author :

Prof. Dr. PT Mpiana,
Prof. Dr. PT Mpiana,
Email:

Received: June 2, 2015,   Accepted: July 6, 2015.   Published:


Abstract:

Some medicinal plants used in Congolese traditional medicine in the management of sickle cell disease have showed interesting antisickling activity in vitro. In the present work, antisickling activity of different extracts from Ocimum canum, a medicinal and aromatic plant used in Congolese traditional medicine, was studied. Aqueous, methanolic, ethyl acetate, n-hexane and dichoromethane extracts were tested using Emmel’s test. Polar extract (Aqueous, methanolic, ethyl acetate) showed antisickling activity when non polar (n-hexane and dichoromethane) were inactive. Anthocyanins extracts from O. canun leaves yielded 8.7 % and showed a strong antisickling activity. This biological activity is dose-dependent and reaches a sickle shape normalization rate of 88.5% at a minimal normalization concentration of 15 µg/ml.


Keywords: Ocimum canum, anthocyanins, antisickling activity, sickle cell disease, normalization rate.


Citation:

PT Mpiana et al. (2015). In vitro Antisickling Activity of Anthocyanins from Ocimum canun (Lamiacea).. J. of Advancement in Medical and Life Sciences. V3I2. DOI: 10.15297/JALS.V3I2.01


Copyright:

© 2015 PT Mpiana. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


      
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      Journal of Advancement in Medical and Life Sciences