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Assessment of the antisickling activity of total methanolic extracts from the rhizomes and roots of C. longa and the effect of photodegradation on the antisickling activity
Research article
  

Assessment of the antisickling activity of total methanolic extracts from the rhizomes and roots of C. longa and the effect of photodegradation on the antisickling activity


Clément M. Mbadiko, Koto-te-Nyiwa Ngbolua1, Pius T. Mpiana, Dorothée D. Tshilanda, Makengo K. Gisèle, Pambu L. Aaron1, Kemfine L. Landry, Bamvingana K. Cyprien3, Bongo N. Gédéon and Mbemba F. Théophile

1Department of Biology, Faculty of Sciences, University of Kinshasa, P.O. Box 190, Kinshasa XI, Democratic Republic of the Congo
2Department of Chemistry, Faculty of Sciences, University of Kinshasa, P.O. Box. 190 Kinshasa XI, Democratic Republic of the Congo
3Chemical, Biological, Radiological and Nuclear Centres of Excellence, Ministry of Scientifc Research, Kinshasa, Democratic Republic of the Congo
4University of Gbadolite, P.O. Box. 111, Gbadolite, Nord-Ubangi Province, Democratic Republic of the Congo


Corresponding author :

Koto-te-Nyiwa Ngbolua,
Tel.: +243 81 68 79 527,
Email:

Received: February 2, 2017,   Accepted: March 7, 2017,   Published:


Abstract:

For centuries, extracts from the rhizomes of C. longa L. were used in Asian and African traditional medicine for the treatment of many diseases. Several studies reported that the extracts of the rhizomes of this plant possess a broad pharmacological potential, nevertheless the studies on the antisickling activity have not been carried out yet and biological studies on other organs of the plant, namely roots remain poor or not yet performed. Using Emmel test, the antisickling activity of total methanolic extracts of rhizomes and roots of this plant was performed. In addition, we assessed the impact of photodegradation on the antisickling action of total methanolic extracts from C. longa rhizomes and roots. To achieve this goal, some of our samples (rhizomes and roots) were dried in the open (i.e. exposed to the sun) and the other part was dried the laboratory temperature under shade. It is known that curcumin, which is the main active ingredient of turmeric longa, degrades in the presence of the UV rays; which justifies the the hypothesis of this work. This study allowed us to conclude that photodegradation has no impact on the antisickling activity of the extracts and all the extracts (total methanolic extracts from rhizomes and roots) showed a good antisickling activity. We suggest further studies that can identify the active compounds responsible of the antisickling activity of C. longa rhizomes and roots as well as to demonstrate their mechanism of action.


Keywords: Curcuma longa, Antisickling activity, Emmel test, Photodegradation.


Citation:

Koto-te-Nyiwa Ngbolua et al. (2017). Assessment of the antisickling activity of total methanolic extracts from the rhizomes and roots of C. longa and the effect of photodegradation on the antisickling activity. J. of Advancement in Medical and Life Sciences. V5I1. DOI: 10.15297/JALS.V5I1.04


Copyright:

© 2017 Koto-te-Nyiwa Ngbolua. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


      
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